Puya Supply Prucalopride CAS 179474-81-8 Treatment of Constipation

• CAS No.: 179474-81-8
• Formula: C18h26cln3o3
• EINECS: 1312995-182-4
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Refined
• Model NO.: PY202211191517
• Colour: White
• Transport Package: 1kg/Aluminum Bag or 25kg/Drum
• Specification: 99% min
• Trademark: Puya
• Origin: China
• Production Capacity: 5000kilogram/Month

Product Description

Puya Supply Prucalopride CAS 179474-81-8 Treatment Of Constipation

Product Name:    Prucalopride
Synonyms:    Prucalopride;4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide;4-Amino-5-chloro-2,3-dihydro-N-(1-(3-methoxypropyl)-4-piperidyl)-7-benzofurancarboxamide;R 093877;R093877;4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide;CS-219;Resolor
CAS:    179474-81-8
MF:    C18H26ClN3O3
MW:    367.87
EINECS:    1312995-182-4
Product Categories:    Inhibitors;API
Mol File:    179474-81-8.mol

Prucalopride is a potent and selective agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Kis = 2.5 and 8 nM for human 5-HT4A and 5-HT4B, respectively). Prucalopride is greater than 250-fold selective for 5-HT4 over a panel of 53 overexpressed receptors, including 5-HT subtypes, but does bind to human dopamine D4 and sigma-1 (σ1) receptors and mouse 5-HT3 receptors (Kis = 2.3, 3.7, and 3.8 μM, respectively). It induces contractions in guinea pig colon with an EC50 value of 33 nM, an effect that is blocked by the 5-HT4 antagonist GR113808 but not the 5-HT2A and 5-HT3 antagonists ketanserin and granisetron , respectively. It also facilitates non-cholinergic contractions induced by electrical stimulation. In fasted dogs, oral administration of prucalopride increases colonic motility by inhibiting distal colon contractions (ED50 = 0.04 mg/kg), an effect that is blocked by pretreatment with the 5-HT4 antagonist GR125487. Prucalopride (5-10 mg/kg, s.c.) increases acetylcholine and histamine levels in the rat prefrontal cortex by 2.4-fold and 3-fold, respectively, and increases the power of hippocampal theta oscillations. Formulations containing prucalopride have been used in the treatment of chronic idiopathic constipation.

Prucalopride CAS 179474-81-8 of Chemical Properties
Melting point     90.7°
Boiling point     481.4±45.0 °C(Predicted)
density     1.28
storage temp.     2-8°C
pka    13.65±0.20(Predicted)
form     powder
color     white to beige

Function and Application of Prucalopride CAS 179474-81-8

1. Procapride is an effective drug for the treatment of chronic constipation with few adverse reactions, mainly headache, dizziness and general adverse reactions such as diarrhea, abdominal pain and nausea, with no significant effect on the heart.

Packing And Shipping
1.Preferentially DHL, FedEX or TNT for quantity less than 50kg, air shipping for 100kg above, sea shipping for quantity over 500kg.
2.For customers from Russia,Mexico,Turkey,Solvenia,Romania,etc,before placing an order,please kindly confirm if you can make clearance when goods reach your customs.

Shipping Terms
By Express	By Air	By Sea
Suitable for under 50kg Fast:3-4 days High cost Door to door service Easy to pick up the goods	Suitable for more than 50kg Fast:3-4 days High cost Airport to airport Professional broker needed	Suitable for more than 500kg Slow:15-30 days Low cost Port to port Professional broker needed

 

Company Profile
Anhui puya biological technology co.,ltd was established in Hefei. Registered capital is 5 million. It is specialized in manufacture plant extract, API and chemicals raw material powder, food additives and oil. which are applied to skin care, healthcare, weight loss products, sex improvement, and pharmaceuticals. We will uphold honesty and pragmatic, innovative and enterprising service purposes, and provide a variety of quality services to our customers at abroad. It aims at supplying good product and comfort service. The strict quality control is to meet the customer's requirement, to get a highly praised and to be high quality supplier. If you have any question, or need samples, please feel free to contact us.

FAQ
Q1. What's the MOQ?
A: Usually 1 kg.  It is based on the different product. Some are 1g and some are 1 ton. Please be free to consult our salesman.
 
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately.  By FedEx will be 3~5 days to you.
 
Q3. If I need less than the MOQ, is it possible?
A: Yes. Please be free to consult our salesman.
 
Q4. Can you supply the free sample?
A: Usually it is possible. but the shipping cost be paid by customers. It based on the different product. Please be free to consult our salesman.
 
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers. The shelf life will be 2 years.
 
Q6: What's your main payment method?
A: T/T, trade assurance, west union, money gram.
 
Q7: Do you have COA, MSDS, CO, Health certificate, form 9 or other certificate?
A: Yes, we have. pls be free to contact us to get updated one.