High Quality Tacrolimus CAS 104987-11-3

• CAS No.: 104987-11-3
• Formula: C44 H69 N O12
• EINECS: 1308068-626-2
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Refined
• Model NO.: PY202210201643
• Colour: Yellow
• Transport Package: 1kg/Aluminum Bag or 25kg/Drum
• Specification: 99% min
• Trademark: Puya
• Origin: China
• Production Capacity: 5000kilogram/Month

Product Description

High Quality Tacrolimus CAS 104987-11-3

Product Name:    Tacrolimus
Synonyms:    (2-propenyl)-,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*,8s*,9e,12r*,14r*,15s*,16r*,18s*;,19s*,26ar*))-;16-dimethoxy-4,10,12,18-tetramethyl-8-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1;15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-;L 679934;Protopic;FK-506:FR-900506;Fujimycin Prozraf
CAS:    104987-11-3
MF:    C44 H69 N O12
MW:    804.02
EINECS:    1308068-626-2
Product Categories:    Inhibitors;API;Active Pharmaceutical Ingredients;Immunosuppressant.;Chiral Reagents;Fujimycin, Prograf;Intermediates & Fine Chemicals;Pharmaceuticals;antibiotic;APIs
Mol File:    104987-11-3.mol

Tacrolimus is a macrolide isolated from Streptomyces spp. It has a strong immunosuppressive effect, binding specifically to and inhibiting calmodulin phosphatase activity and inhibiting IL-2 signaling transcription, thereby inhibiting T-cell activation, TNF-α, IL-1β and IL-6 production and T-cell-dependent B-cell proliferation. Compared with cyclosporine, another calmodulin phosphatase inhibitor, tacrolimus inhibits T-cell activation more strongly and has fewer adverse effects.


Tacrolimus CAS 104987-11-3 of Chemical Properties
Melting point     113-115°C
Boiling point     871.7±75.0 °C(Predicted)
density     1.19±0.1 g/cm3(Predicted)
Fp     2ºC
storage temp.     Sealed in dry,Store in freezer, under -20°C
solubility     DMSO: >3 mg/mL
pka    9.97±0.70(Predicted)
form     solid
color     white
Water Solubility     Freely soluble in DMSO or ethanol. Poorly soluble in water.Soluble in dimethyl sulfoxide, ethanol, water, acet one, chloro form, ethyl acet ate, ether, methan ol and dimethyl formamide.
Stability:    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
InChIKey    QJJXYPPXXYFBGM-LFZNUXCKSA-N
CAS DataBase Reference    104987-11-3(CAS DataBase Reference)

Function and Application of Tacrolimus CAS 104987-11-3
1. Tacrolimus is a macrolide antibiotics. Immunosuppressants. Same mechanism of action as cyclosporine, mainly inhibits the synthesis of interleukin-2. Used for rejection of organ transplants
2. A macrolide that binds to FK506 binding protein (FKBP) to form a complex that reduces peptidyl prolyl isomerase activity in T cells.
3. FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system
4. Tacrolimus for use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was first approved by the FDA in 1994 for use in liver transplantation, this has been extended to include kidney, heart,


Packing And Shipping
1.Preferentially DHL, FedEX or TNT for quantity less than 50kg, air shipping for 100kg above, sea shipping for quantity over 500kg.
2.For customers from Russia,Mexico,Turkey,Solvenia,Romania,etc,before placing an order,please kindly confirm if you can make clearance when goods reach your customs.

Shipping Terms
By Express	By Air	By Sea
Suitable for under 50kg Fast:3-4 days High cost Door to door service Easy to pick up the goods	Suitable for more than 50kg Fast:3-4 days High cost Airport to airport Professional broker needed	Suitable for more than 500kg Slow:15-30 days Low cost Port to port Professional broker needed

 

Company Profile
Anhui puya biological technology co.,ltd was established in Hefei. Registered capital is 5 million. It is specialized in manufacture plant extract, API and chemicals raw material powder, food additives and oil. which are applied to skin care, healthcare, weight loss products, sex improvement, and pharmaceuticals. We will uphold honesty and pragmatic, innovative and enterprising service purposes, and provide a variety of quality services to our customers at abroad. It aims at supplying good product and comfort service. The strict quality control is to meet the customer's requirement, to get a highly praised and to be high quality supplier. If you have any question, or need samples, please feel free to contact us.

FAQ
Q1. What's the MOQ?
A: Usually 1 kg.  It is based on the different product. Some are 1g and some are 1 ton. Please be free to consult our salesman.
 
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately.  By FedEx will be 3~5 days to you.
 
Q3. If I need less than the MOQ, is it possible?
A: Yes. Please be free to consult our salesman.
 
Q4. Can you supply the free sample?
A: Usually it is possible. but the shipping cost be paid by customers. It based on the different product. Please be free to consult our salesman.
 
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers. The shelf life will be 2 years.
 
Q6: What's your main payment method?
A: T/T, trade assurance, west union, money gram.
 
Q7: Do you have COA, MSDS, CO, Health certificate, form 9 or other certificate?
A: Yes, we have. pls be free to contact us to get updated one.