Top Grade Bosutinib CAS 380843-75-4 Treatment of Cancer

• CAS No.: 380843-75-4
• Formula: C26h29cl2n5o3
• EINECS: 700-455-1
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Refined
• Model NO.: PY202210151756
• Colour: White
• Transport Package: 1kg/Aluminum Bag or 25kg/Drum
• Specification: 99% min
• Trademark: Puya
• Origin: China
• Production Capacity: 5000kilogram/Month

Product Description

Top Grade Bosutinib CAS 380843-75-4 Treatment Of Cancer

Product Name:    Bosutinib
Synonyms:    4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile;Bosutinib ( SKI-606 );Bsutinib;SKI 606 - Bosutinib;CS-311;Bosutinib for research;3-Quinolinecarbonitrile, 4-[(2,4-dichloro-5-Methoxyphenyl)aMino]-6-Methoxy-7-[3-(4-Methyl-1-piperazinyl)propoxy]-;Bosutinib(TINIBS )
CAS:    380843-75-4
MF:    C26H29Cl2N5O3
MW:    530.45
EINECS:    700-455-1
Product Categories:    Aromatics;Heterocycles;API;Aromatics Compounds;Inhibitors;Intermediates & Fine Chemicals;Pfizer compounds;Pharmaceuticals
Mol File:    380843-75-4.mol


In September 2012, the US FDA approved bosutinib (also referred to as SKI-607) for the treatment of relapsed or refractory chronicmyeloid leukemia (CML) for patients with resistance or intolerance to prior therapy. The National Cancer Institute estimates that in 2012, 5430 men and women were diagnosed with CML and 610 died of CML. First and second-line therapies for the treatment of CML include imatinib, dasatinib, and nilotinib. Bosutinib, which was initially identified as a Src inhibitor, was later found to be a dual inhibitor of Bcr-Abl (IC50=1.4 nM) and Src family kinases (IC50=3.5 nM). Bosutinib inhibits 16 of 18 imatinib-resistant forms of Bcr-Abl expressed in murine myeloid cell lines. In preclinical in vivo studies, bosutinib at 15 mg/kg administered orally for 5 days caused regression of K562 CML tumors in nude mice and in BaF3 tumors expressing wild type or different imatinib-resistant Bcr-Abl mutants at varying doses. A manufacturing process for the synthesis of bosutinib monohydrate has been reported that employs a key three-component cyclization reaction involving an anili ne, a cyanoacetamide intermediate, and triethyl orthofor mate followed by cyclization using phosphorous oxytrichloride and an optimized hydration procedure.

Bosutinib CAS 380843-75-4 of Chemical Properties
Melting point     116-120 ºC
Boiling point     649.7±55.0 °C(Predicted)
density     1.36
vapor pressure     0-0Pa at 20ºC
storage temp.     room temp
solubility     DMSO: ≥15mg/mL
form     powder
pka    7.63±0.10(Predicted)
color     off-white to light brown
Stability:    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey    PICKMQXYAMDEPF-UHFFFAOYSA-N
LogP    3.3-4.3 at pH9.5
Surface tension    72.4mN/m at 3.6mg/L and 20ºC
CAS DataBase Reference    380843-75-4(CAS DataBase Reference)

Function and Application of Bosutinib CAS 380843-75-4
Bosutinib (CAS 380843-75-4) is a tyrosine kinase inhibitor that selectively targets the BCR-ABL1 fusion protein, which is responsible for the growth and survival of leukemic cells in chronic myeloid leukemia (CML). Bosutinib was approved by the FDA in 2012 for the treatment of adult patients with newly diagnosed CML in the chronic phase, as well as for patients with CML who have progressed after previous treatment.

The function of Bosutinib is to inhibit the activity of the BCR-ABL1 fusion protein, which is a constitutively active tyrosine kinase that promotes the proliferation and survival of leukemic cells. By inhibiting this protein, Bosutinib can reduce the growth and survival of leukemic cells, leading to improved outcomes for patients with CML.

The applications of Bosutinib are primarily in the treatment of CML, including both newly diagnosed patients and those who have previously received treatment. It may also be used off-label for the treatment of other malignancies that are driven by tyrosine kinases, such as gastrointestinal stromal tumors (GIST) and acute lymphoblastic leukemia (ALL). Bosutinib may be used alone or in combination with other drugs, depending on the specific treatment plan developed by the healthcare provider.


Packing And Shipping
1.Preferentially DHL, FedEX or TNT for quantity less than 50kg, air shipping for 100kg above, sea shipping for quantity over 500kg.
2.For customers from Russia,Mexico,Turkey,Solvenia,Romania,etc,before placing an order,please kindly confirm if you can make clearance when goods reach your customs.

Shipping Terms
By Express	By Air	By Sea
Suitable for under 50kg Fast:3-4 days High cost Door to door service Easy to pick up the goods	Suitable for more than 50kg Fast:3-4 days High cost Airport to airport Professional broker needed	Suitable for more than 500kg Slow:15-30 days Low cost Port to port Professional broker needed

 

Company Profile
Anhui puya biological technology co.,ltd was established in Hefei. Registered capital is 5 million. It is specialized in manufacture plant extract, API and chemicals raw material powder, food additives and oil. which are applied to skin care, healthcare, weight loss products, sex improvement, and pharmaceuticals. We will uphold honesty and pragmatic, innovative and enterprising service purposes, and provide a variety of quality services to our customers at abroad. It aims at supplying good product and comfort service. The strict quality control is to meet the customer's requirement, to get a highly praised and to be high quality supplier. If you have any question, or need samples, please feel free to contact us.

FAQ
Q1. What's the MOQ?
A: Usually 1 kg.  It is based on the different product. Some are 1g and some are 1 ton. Please be free to consult our salesman.
 
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately.  By FedEx will be 3~5 days to you.
 
Q3. If I need less than the MOQ, is it possible?
A: Yes. Please be free to consult our salesman.
 
Q4. Can you supply the free sample?
A: Usually it is possible. but the shipping cost be paid by customers. It based on the different product. Please be free to consult our salesman.
 
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers. The shelf life will be 2 years.
 
Q6: What's your main payment method?
A: T/T, trade assurance, west union, money gram.
 
Q7: Do you have COA, MSDS, CO, Health certificate, form 9 or other certificate?
A: Yes, we have. pls be free to contact us to get updated one.