Puya Supply Tacrolimus CAS 104987-11-3 for Immunosuppression

• CAS No.: 104987-11-3
• Formula: C44 H69 N O12
• EINECS: 1308068-626-2
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Refined
• Model NO.: PY202303051156
• Colour: White
• Transport Package: 1gram/Bag
• Specification: 99% min
• Trademark: Puya
• Origin: China
• Production Capacity: 5000kilogram/Month

Product Description

Puya Supply Tacrolimus CAS 104987-11-3 For Immunosuppression

Product Name:    Tacrolimus
Synonyms:    (2-propenyl)-,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*,8s*,9e,12r*,14r*,15s*,16r*,18s*;,19s*,26ar*))-;16-dimethoxy-4,10,12,18-tetramethyl-8-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1;15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-;L 679934;Protopic;FK-506:FR-900506;Fujimycin Prozraf
CAS:    104987-11-3
MF:    C44 H69 N O12
MW:    804.02
EINECS:    1308068-626-2
Product Categories:    Inhibitors;API;Active Pharmaceutical Ingredients;Immunosuppressant.;Chiral Reagents;Fujimycin, Prograf;Intermediates & Fine Chemicals;Pharmaceuticals;antibiotic;APIs;104987-11-3
Mol File:    104987-11-3.mol


Tacrolimus, also known as FK506, is an immunosuppressive drug used to prevent rejection in organ transplantation. Its CAS number is 104987-11-3. It was first isolated in 1987 from the fermentation broth of the bacterium Streptomyces tsukubaensis, and was approved by the FDA in 1994 for use in liver transplantation.

Tacrolimus CAS 104987-11-3 of Chemical Properties
Melting point     113-115°C
Boiling point     871.7±75.0 °C(Predicted)
density     1.19±0.1 g/cm3(Predicted)
Fp     2ºC
storage temp.     Sealed in dry,Store in freezer, under -20°C
solubility     DMSO: >3 mg/mL
form     solid
pka    9.97±0.70(Predicted)
color     white
Water Solubility     Freely soluble in DMSO or ethanol. Poorly soluble in water.Soluble in dimethyl sulfoxide, ethanol, water, ace tone, chloro form, ethyl aceta te, ether, methan ol and dimethyl formamide.
Stability:    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
InChIKey    QJJXYPPXXYFBGM-LFZNUXCKSA-N
CAS DataBase Reference    104987-11-3(CAS DataBase Reference)


Function and Application of Tacrolimus CAS 104987-11-3

Tacrolimus, also known as FK506, is a potent immunosuppressive drug that is primarily used to prevent organ rejection in transplant patients. It is a macrolide lactone isolated from the bacterium Streptomyces tsukubaensis.

Function:
Tacrolimus works by inhibiting the activation and proliferation of T-lymphocytes, which are responsible for the body's immune response. Specifically, it binds to a protein called FK-binding protein-12 (FKBP-12), which then inhibits the activity of calcineurin, a key enzyme involved in T-cell activation. This results in reduced cytokine production and decreased immune response, ultimately preventing rejection of transplanted organs.

Application:
Tacrolimus is approved by the FDA for use in liver, kidney, and heart transplant recipients. It may also be used off-label to treat other autoimmune diseases such as rheumatoid arthritis and psoriasis. Tacrolimus is typically administered orally, either as a capsule or a liquid solution, and is sometimes combined with other immunosuppressive drugs such as corticosteroids.

In addition to its use in transplantation, Tacrolimus has been studied for its potential in treating other conditions such as atopic dermatitis, uveitis, and ulcerative colitis. It has also been investigated for its potential as an anti-cancer agent due to its ability to inhibit T-cell activation and proliferation. However, more research is needed in these areas to determine the safety and effectiveness of Tacrolimus in these indications.

Packing And Shipping
1.Preferentially DHL, FedEX or TNT for quantity less than 50kg, air shipping for 100kg above, sea shipping for quantity over 500kg.
2.For customers from Russia,Mexico,Turkey,Solvenia,Romania,etc,before placing an order,please kindly confirm if you can make clearance when goods reach your customs.

Shipping Terms
By Express	By Air	By Sea
Suitable for under 50kg Fast:3-4 days High cost Door to door service Easy to pick up the goods	Suitable for more than 50kg Fast:3-4 days High cost Airport to airport Professional broker needed	Suitable for more than 500kg Slow:15-30 days Low cost Port to port Professional broker needed

 

Company Profile
Anhui puya biological technology co.,ltd was established in Hefei. Registered capital is 5 million. It is specialized in manufacture plant extract, API and chemicals raw material powder, food additives and oil. which are applied to skin care, healthcare, weight loss products, sex improvement, and pharmaceuticals. We will uphold honesty and pragmatic, innovative and enterprising service purposes, and provide a variety of quality services to our customers at abroad. It aims at supplying good product and comfort service. The strict quality control is to meet the customer's requirement, to get a highly praised and to be high quality supplier. If you have any question, or need samples, please feel free to contact us.

FAQ
Q1. What's the MOQ?
A: Usually 1 kg.  It is based on the different product. Some are 1g and some are 1 ton. Please be free to consult our salesman.
 
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately.  By FedEx will be 3~5 days to you.
 
Q3. If I need less than the MOQ, is it possible?
A: Yes. Please be free to consult our salesman.
 
Q4. Can you supply the free sample?
A: Usually it is possible. but the shipping cost be paid by customers. It based on the different product. Please be free to consult our salesman.
 
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers. The shelf life will be 2 years.
 
Q6: What's your main payment method?
A: T/T, trade assurance, west union, money gram.
 
Q7: Do you have COA, MSDS, CO, Health certificate, form 9 or other certificate?
A: Yes, we have. pls be free to contact us to get updated one.