High Quality Lonidamine CAS 50264-69-2 Treatment of Cancer

• CAS No.: 50264-69-2
• Formula: C15h10cl2n2o2
• EINECS: 256-510-0
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Refined
• Model NO.: PY202211161405
• Colour: White
• Transport Package: 1kg/Aluminum Bag or 25kg/Drum
• Specification: 99% min
• Trademark: Puya
• Origin: China
• Production Capacity: 5000kilogram/Month

Product Description

High Quality Lonidamine CAS 50264-69-2 Treatment Of Cancer

Product Name:    Lonidamine
Synonyms:    af1890;lonidamin;1-[(2,4-dichlorophenyl)methyl]indazole-3-carboxylic acid;1H-Indazole-3-carboxylicacid, 1-[(2,4-dichlorophenyl)Methyl]-;1-(2,4-dichlorbenzyl)-indazole-3-carboxylicacid;1-(2,4-dichlorobenzyl)-1h-indazole-3-carboxylicaci;Lonidamine (AF1890);Lonidamine, 99%, mitochondrial hexokinase inhibitor
CAS:    50264-69-2
MF:    C15H10Cl2N2O2
MW:    321.16
EINECS:    256-510-0
Product Categories:    API;DORIDAMINA;inhibitor;Anti-cancer&immunity
Mol File:    50264-69-2.mol


Lonidamine is a derivative of indazole-3-carboxylic acid. It is a kind of orally administrated small molecule, which can inhibit the glycolysis process through inactivating the hexokinase (the first step in glycolysis). It has been shown that cancer cell primarily generates energy through glycolysis process. Therefore, Lonidamine has been used for the treatment of several kinds of cancers. One special property of Lonidamine is that it seems to enhance aerobic glycolysis in normal cells, but inhibit glycolysis only in cancer cells. In addition, there are also evidences that Lonidamine may increase the occurrence of apoptosis. It has also been shown that Lonidamine is effective in the treatment of benigh prostatic hyperplasia (BPH).

Lonidamine CAS 50264-69-2 of Chemical Properties
Melting point     207-209°C
Boiling point     537.9±45.0 °C(Predicted)
density     1.4835 (rough estimate)
refractive index     1.6070 (estimate)
storage temp.     Sealed in dry,2-8°C
solubility     Soluble in DMSO (up to 25 mg/ml).
pka    3.00±0.10(Predicted)
form     solid
color     White
Stability:    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey    WDRYRZXSPDWGEB-UHFFFAOYSA-N
CAS DataBase Reference    50264-69-2(CAS DataBase Reference)


Function and Application of Lonidamine CAS 50264-69-2

1.  Lonidamine does not affect cell proliferation, but mainly acts on the energy metabolism of cells. It reduces the glycolysis of tumour cells by altering the mitochondrial ultrastructure of tumour cells, inhibiting the activity of hexokinase that binds to mitochondria, and affects the expression of apoptosis-related proteins, inhibiting the oxygen consumption of malignant cells to achieve the purpose of killing tumour cells. It can be used in the treatment of various tumours such as breast cancer, prostate cancer, lung cancer and brain tumours, etc. It is being increasingly studied and applied because of its broad anti-cancer spectrum and low side effects.
2. Lonidamine can be used for various tumours such as breast, prostate and lung cancers and brain tumours. Also a spermicidal agent.


Packing And Shipping
1.Preferentially DHL, FedEX or TNT for quantity less than 50kg, air shipping for 100kg above, sea shipping for quantity over 500kg.
2.For customers from Russia,Mexico,Turkey,Solvenia,Romania,etc,before placing an order,please kindly confirm if you can make clearance when goods reach your customs.

Shipping Terms
By Express	By Air	By Sea
Suitable for under 50kg Fast:3-4 days High cost Door to door service Easy to pick up the goods	Suitable for more than 50kg Fast:3-4 days High cost Airport to airport Professional broker needed	Suitable for more than 500kg Slow:15-30 days Low cost Port to port Professional broker needed

 

Company Profile
Anhui puya biological technology co.,ltd was established in Hefei. Registered capital is 5 million. It is specialized in manufacture plant extract, API and chemicals raw material powder, food additives and oil. which are applied to skin care, healthcare, weight loss products, sex improvement, and pharmaceuticals. We will uphold honesty and pragmatic, innovative and enterprising service purposes, and provide a variety of quality services to our customers at abroad. It aims at supplying good product and comfort service. The strict quality control is to meet the customer's requirement, to get a highly praised and to be high quality supplier. If you have any question, or need samples, please feel free to contact us.

FAQ
Q1. What's the MOQ?
A: Usually 1 kg.  It is based on the different product. Some are 1g and some are 1 ton. Please be free to consult our salesman.
 
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately.  By FedEx will be 3~5 days to you.
 
Q3. If I need less than the MOQ, is it possible?
A: Yes. Please be free to consult our salesman.
 
Q4. Can you supply the free sample?
A: Usually it is possible. but the shipping cost be paid by customers. It based on the different product. Please be free to consult our salesman.
 
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers. The shelf life will be 2 years.
 
Q6: What's your main payment method?
A: T/T, trade assurance, west union, money gram.
 
Q7: Do you have COA, MSDS, CO, Health certificate, form 9 or other certificate?
A: Yes, we have. pls be free to contact us to get updated one.