High Quality Methazolamide CAS 554-57-4 Treatment of Glaucoma

• CAS No.: 554-57-4
• Formula: C5h8n4o3s2
• EINECS: 209-066-7
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Refined
• Model NO.: PY202211161453
• Colour: White
• Transport Package: 1kg/Aluminum Bag or 25kg/Drum
• Specification: 99% min
• Trademark: Puya
• Origin: China
• Production Capacity: 5000kilogram/Month

Product Description

High Quality Methazolamide CAS 554-57-4 Treatment Of Glaucoma

Product Name:    Methazolamide
Synonyms:    2-acetylimino-3-methyl-delta(sup4)-1,3,4-thiadiazoline-5-sulfonamide;2-Acetylimino-3-methyl-delta4-1,3,4-thiadiazoline-5-sulfonamide;5-acetylimino-4-methyl-delta(sup2)-1,3,4-thiadiazoline-2-sulfonamide;CL 8490;N-[5-(Aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide;N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide;N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)ethanamide;Methazolamide (500 mg)
CAS:    554-57-4
MF:    C5H8N4O3S2
MW:    236.27
EINECS:    209-066-7
Product Categories:    VANDID;Other APIs;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Seleni um Compounds
Mol File:    554-57-4.mol


Methazolamide is a carbonic anhydrase inhibitor (IC50 = 130 nM). It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide reduces electroshock-induced seizures in rats with an ED50 value of 19.2 mg/kg. It also inhibits production of reactive oxygen species (ROS) in a primary cortical neuron (PCN) cellular model of subarachnoid hemorrhage (SAH) and reduces cerebral edema in a mouse model of SAH. Methazolamide is larvicidal, with a larvicidal concentration (LC50) value of 724 ppm, but has no activity when administered in the diet to adult A. aegypti. Formulations containing methazolamide have been used for the treatment of glaucoma.

Methazolamide CAS 554-57-4 of Chemical Properties
Melting point     208 °C (dec.) (lit.)
Boiling point     402.0±28.0 °C(Predicted)
density     1.6625 (rough estimate)
refractive index     1.6270 (estimate)
storage temp.     2-8°C
solubility     DMSO: soluble20mg/mL, clear
form     White powder
pka    7.30(at 25ºC)
color     white to beige
Water Solubility     2.835g/L(25 ºC)
InChIKey    FLOSMHQXBMRNHR-QPJJXVBHSA-N
CAS DataBase Reference    554-57-4(CAS DataBase Reference)
NIST Chemistry Reference    Methazolamide(554-57-4)
EPA Substance Registry System    Acetamide, N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]- (554-57-4)

Function and Application of Methazolamide CAS 554-57-4

1. Methazolamide is a carbonic anhydrase inhibitor. Methazolamide is used in the treatment of glaucoma.
2. Action of this drug is similar to that of acetazolamide, and it is used for lowering intraocular pressure in treating wide-angle and secondary glaucoma, and before surgical intervention for severe wide-angle glaucoma.


Packing And Shipping
1.Preferentially DHL, FedEX or TNT for quantity less than 50kg, air shipping for 100kg above, sea shipping for quantity over 500kg.
2.For customers from Russia,Mexico,Turkey,Solvenia,Romania,etc,before placing an order,please kindly confirm if you can make clearance when goods reach your customs.

Shipping Terms
By Express	By Air	By Sea
Suitable for under 50kg Fast:3-4 days High cost Door to door service Easy to pick up the goods	Suitable for more than 50kg Fast:3-4 days High cost Airport to airport Professional broker needed	Suitable for more than 500kg Slow:15-30 days Low cost Port to port Professional broker needed

 

Company Profile
Anhui puya biological technology co.,ltd was established in Hefei. Registered capital is 5 million. It is specialized in manufacture plant extract, API and chemicals raw material powder, food additives and oil. which are applied to skin care, healthcare, weight loss products, sex improvement, and pharmaceuticals. We will uphold honesty and pragmatic, innovative and enterprising service purposes, and provide a variety of quality services to our customers at abroad. It aims at supplying good product and comfort service. The strict quality control is to meet the customer's requirement, to get a highly praised and to be high quality supplier. If you have any question, or need samples, please feel free to contact us.

FAQ
Q1. What's the MOQ?
A: Usually 1 kg.  It is based on the different product. Some are 1g and some are 1 ton. Please be free to consult our salesman.
 
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately.  By FedEx will be 3~5 days to you.
 
Q3. If I need less than the MOQ, is it possible?
A: Yes. Please be free to consult our salesman.
 
Q4. Can you supply the free sample?
A: Usually it is possible. but the shipping cost be paid by customers. It based on the different product. Please be free to consult our salesman.
 
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers. The shelf life will be 2 years.
 
Q6: What's your main payment method?
A: T/T, trade assurance, west union, money gram.
 
Q7: Do you have COA, MSDS, CO, Health certificate, form 9 or other certificate?
A: Yes, we have. pls be free to contact us to get updated one.