Puya Supply Nintedanib CAS 656247-17-5 Treatment for Interstitial Lung Fibrosis

• CAS No.: 656247-17-5
• Formula: C31h33n5o4
• EINECS: 1592732-453-0
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Refined
• Model NO.: PY202211011520
• Colour: White
• Transport Package: 1kg/Aluminum Bag or 25kg/Drum
• Specification: 99% min
• Trademark: Puya
• Origin: China
• Production Capacity: 5000kilogram/Month

Product Description

Puya Supply Nintedanib CAS 656247-17-5 Treatment For Interstitial lung fibrosis

Product Name:    Nintedanib
Synonyms:    INTEDANIB BASE;Nintedanib;Nintedanib (BIBF 1120);Nintedanib/Intedanib/Vargatef;BIBF 1120; VARGATEF; INTEDANIB;INTEDANIB BASE;Intedanib Vargatef;Nintedanib-016;100837
CAS:    656247-17-5
MF:    C31H33N5O4
MW:    539.64
EINECS:    1592732-453-0
Product Categories:    API;Heterocycles;Amines;Intermediates & Fine Chemicals;Pharmaceuticals;Nintedanib;Inhibitors;API
Mol File:    656247-17-5.mol


Idiopathic interstitial pulmonary fibrosis (IPF) is a group of diseases of unknown etiology, characterised by progressive dyspnoea and deterioration of lung function. There is no definitive treatment for IPF other than lung transplantation. In the absence of lung transplantation, the three-year and five-year mortality rates are 50% and 80% respectively. However, with the current scarcity of donors in China and the generally disappointing efficacy of previous anti-interstitial lung fibrosis drugs, respiratory physicians in our clinics are concerned with more effective drug therapy for the benefit of IPF patients. Nedanib, a small molecule tyrosine kinase inhibitorTKI, has provided new research findings for the treatment of IPF.

Nintedanib CAS 656247-17-5 of Chemical Properties
Melting point     >237oC (dec.)
Boiling point     742.2±60.0 °C(Predicted)
density     1.284±0.06 g/cm3(Predicted)
storage temp.     Refrigerator
solubility     DMSO (Slightly), Methan ol (Slightly)
form     Yellow solid.
pka    11.06±0.20(Predicted)
color     Light Yellow to Light Green

Function and Application of Nintedanib CAS 656247-17-5
1. Nintedanib is a small molecule tyrosine kinase inhibitor (TKI) developed by Boehringer Ingelheim specifically for idiopathic pulmonary fibrosis (IPF) [E1] and is the first IPF-targeted therapy with consistent clinical evidence to significantly reduce the annual rate of lung function decline (by up to 50% in Chemicalbook), thereby delaying IPF disease progression. It is the first IPF-targeted therapy that blocks both platelet-derived growth fact or receptors (PDGFR), vascular endothelial growth fact or receptors (VEGFR1-3) and fibroblast growth fact or receptors (FGFR1-3).
2. Nintedanib is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases; an indolinone as triple angiokinase inhibitors. An antitumor agent.



Packing And Shipping
1.Preferentially DHL, FedEX or TNT for quantity less than 50kg, air shipping for 100kg above, sea shipping for quantity over 500kg.
2.For customers from Russia,Mexico,Turkey,Solvenia,Romania,etc,before placing an order,please kindly confirm if you can make clearance when goods reach your customs.

Shipping Terms
By Express	By Air	By Sea
Suitable for under 50kg Fast:3-4 days High cost Door to door service Easy to pick up the goods	Suitable for more than 50kg Fast:3-4 days High cost Airport to airport Professional broker needed	Suitable for more than 500kg Slow:15-30 days Low cost Port to port Professional broker needed

 

Company Profile
Anhui puya biological technology co.,ltd was established in Hefei. Registered capital is 5 million. It is specialized in manufacture plant extract, API and chemicals raw material powder, food additives and oil. which are applied to skin care, healthcare, weight loss products, sex improvement, and pharmaceuticals. We will uphold honesty and pragmatic, innovative and enterprising service purposes, and provide a variety of quality services to our customers at abroad. It aims at supplying good product and comfort service. The strict quality control is to meet the customer's requirement, to get a highly praised and to be high quality supplier. If you have any question, or need samples, please feel free to contact us.

FAQ
Q1. What's the MOQ?
A: Usually 1 kg.  It is based on the different product. Some are 1g and some are 1 ton. Please be free to consult our salesman.
 
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately.  By FedEx will be 3~5 days to you.
 
Q3. If I need less than the MOQ, is it possible?
A: Yes. Please be free to consult our salesman.
 
Q4. Can you supply the free sample?
A: Usually it is possible. but the shipping cost be paid by customers. It based on the different product. Please be free to consult our salesman.
 
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers. The shelf life will be 2 years.
 
Q6: What's your main payment method?
A: T/T, trade assurance, west union, money gram.
 
Q7: Do you have COA, MSDS, CO, Health certificate, form 9 or other certificate?
A: Yes, we have. pls be free to contact us to get updated one.