Pharmaceutical Raw Material Powder CAS 134523-03-8 Atorvastatin Calcium

• Function: Vitamins and Minerals Deficiency Drug
• Grade Standard: Medicine Grade
• Type: Chemical Reagent
• State: Powder
• Volatile: Not Volatile
• CAS: 134523-03-8
• Model NO.: py0434
• Mf.: C66h68caf2n4o10
• Einecs: 200-659-6
• Standard: USP Bp Ep
• Transport Package: 10kg/Drum
• Specification: 99%
• Trademark: puya
• Origin: China
• Production Capacity: 10ton/Year

Product Description

CAS 134523-03-8 Atorvastatin Calcium

CAS: 134523-03-8
MF: C66H68CaF2N4O10
MW: 1155.36
EINECS: 200-659-6
Melting point: 176-178°C
Storage temp.: Store at +4°C
Appearance: White Crystalline Powder

Specification

Items	Standard	Results
APPEARANCE	Off white to white powder	White powder
IDENTIFICATION	A: IR B: Retention time	Complies Complies
WATER	≤0.5%	0.06%
HEAVY METALS	≤0.002%	Complies
ISOMERS	SFBD1≤0.15%	Undetected
	SFBD2≤0.15%	Undetected
	SFBE≤0.15%	Undetected
RELATED SUBSTANCES	SFBA-1≤0.15%	0.04%
	SFBMA≤0.15%	Undetected
	CHLORO-SFB≤0.15%	0.05%
	DiSFBMA-SFB≤0.15%	0.02%
	Methyl-SFB≤0.15%	Undetected
	Pentafluoro-phenol≤0.15%	Undetected
	Amino-SFB≤0.15%	Undetected
	Any unknown impurity≤0.1%	0.04%
	Total impurity≤1.0%	0.21%
ASSAY	≥99.0%	99.8%
RESULT:  It complies to prescribed enterprise standard

Function
Lipitor was launched in Canada, the Netherlands, the UK and the US as an orally-active hypocholesterolemic agent.
It was the first pharmaceutical product ever to attain over one billion dollars in sales in its first year. It can be
synthesized by a number of routes but the most efficient involves the Paal-Knorr reaction of an acetonide protected
dihydroxy amino ester and a diaryl phenylacetamide diketone. Lipitor is a liver selective, reversible competitive
inhibitor of HMG-CoA reductase, the rate limiting step in cholesterol biosynthesis. Lipitor monotherapy resulted
in a reduction of LDL cholesterol by up to 60%. Lipitor is about 2-4 times more potent, on a dosage basis, than
Simvastatin.

Application
A selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated
for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia..