Puya Supply Lorlatinib / Ap26113 CAS 1197958-12-5 for Anti Cancer

• CAS No.: 1197958-12-5
• Formula: C26h34cln6o2p
• EINECS: 234-394-2
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Refined
• Model NO.: PY202209281914
• Colour: White
• Transport Package: 1kg/Aluminum Bag or 25kg/Drum
• Specification: 99% min
• Trademark: Puya
• Origin: China
• Production Capacity: 5000kilogram/Month

Product Description

Puya Supply Lorlatinib / AP26113 CAS 1197958-12-5 For Anti Cancer

Product Name:    AP26113
Synonyms:    5-chloro-2-N-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl]-4-N-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine;AP26113-ANALOG;(2-((5-Chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)ami;AP26113;AP26113/AP-26113;5-chloro-N2-(4-(4-(diMethylaMino)piperidin-1-yl)-2-Methoxy-5-Methylphenyl)-N4-(2-(diMethylphosphoryl)phenyl)pyriMidine-2,4-diaMine;5-Chloro-N2-[4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl]-N4-[2-(dimethylphosphinyl)phenyl]-2,4-pyrimidinediamine;5-Chloro-N2-[4-[4-(diMethylaMino)-1-piperidinyl]-2-Methoxyphenyl]-N4-[2-(diMethylphosphinyl)phenyl]
CAS:    1197958-12-5
MF:    C26H34ClN6O2P
MW:    529.01
EINECS:    234-394-2
Product Categories:    Inhibitors;API
Mol File:    1197958-12-5.mol

AP26113 (also known as Brigatinib) is an investigated small molecule for targeted cancer therapy. It is a potent dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth fact or receptor (EGFR). It is mainly under investigation for its treatmentefficacy on non-small cell lung cancer (NSCLC) where ALK is activated and EGFP mutations frequently occur.

Lorlatinib / AP26113 CAS 1197958-12-5 of Chemical Properties
Boiling point     737.6±70.0 °C(Predicted)
density     1.29±0.1 g/cm3(Predicted)
solubility     ≥26.45 mg/mL in DMSO; insoluble in H2O; ≥55.9 mg/mL in EtOH
form     solid
pka    9.27±0.20(Predicted)
CAS DataBase Reference    1197958-12-5

Function and Application of Lorlatinib / AP26113 CAS 1197958-12-5

Lorlatinib, also known as AP26113, is a small-molecule tyrosine kinase inhibitor that targets specific mutations in the anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) genes, which are commonly found in certain types of cancer. Its CAS number is 1197958-12-5.

Lorlatinib works by blocking the activity of the abnormal ALK and ROS1 proteins, which are involved in the growth and survival of cancer cells. It has shown promising results in preclinical and clinical studies, particularly in patients with ALK-positive or ROS1-positive non-small cell lung cancer (NSCLC) who have developed resistance to other ALK inhibitors.

Some of the functions and applications of lorlatinib include:

Treatment of ALK-positive and ROS1-positive NSCLC: Lorlatinib has been approved by the US FDA for the treatment of ALK-positive and ROS1-positive NSCLC in patients who have already received other ALK inhibitors and have developed resistance. It has demonstrated high response rates and durable clinical benefit in these patients.

Inhibition of ALK and ROS1 mutations: Lorlatinib has been shown to effectively inhibit several different ALK and ROS1 mutations that are known to cause resistance to other ALK inhibitors, making it a promising therapeutic option for patients with advanced NSCLC.

Brain penetration: Lorlatinib has the ability to penetrate the blood-brain barrier, which is important for the treatment of NSCLC that has metastasized to the brain. It has shown efficacy in controlling brain metastases in patients with ALK-positive NSCLC.

Potential for combination therapy: Lorlatinib has shown synergistic effects when used in combination with other cancer therapies, such as immune checkpoint inhibitors and chemotherapy, and may be used in combination with other agents to enhance its therapeutic potential.

Packing And Shipping
1.Preferentially DHL, FedEX or TNT for quantity less than 50kg, air shipping for 100kg above, sea shipping for quantity over 500kg.
2.For customers from Russia,Mexico,Turkey,Solvenia,Romania,etc,before placing an order,please kindly confirm if you can make clearance when goods reach your customs.

Shipping Terms
By Express	By Air	By Sea
Suitable for under 50kg Fast:3-4 days High cost Door to door service Easy to pick up the goods	Suitable for more than 50kg Fast:3-4 days High cost Airport to airport Professional broker needed	Suitable for more than 500kg Slow:15-30 days Low cost Port to port Professional broker needed

 

Company Profile
Anhui puya biological technology co.,ltd was established in Hefei. Registered capital is 5 million. It is specialized in manufacture plant extract, API and chemicals raw material powder, food additives and oil. which are applied to skin care, healthcare, weight loss products, sex improvement, and pharmaceuticals. We will uphold honesty and pragmatic, innovative and enterprising service purposes, and provide a variety of quality services to our customers at abroad. It aims at supplying good product and comfort service. The strict quality control is to meet the customer's requirement, to get a highly praised and to be high quality supplier. If you have any question, or need samples, please feel free to contact us.

FAQ
Q1. What's the MOQ?
A: Usually 1 kg.  It is based on the different product. Some are 1g and some are 1 ton. Please be free to consult our salesman.
 
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately.  By FedEx will be 3~5 days to you.
 
Q3. If I need less than the MOQ, is it possible?
A: Yes. Please be free to consult our salesman.
 
Q4. Can you supply the free sample?
A: Usually it is possible. but the shipping cost be paid by customers. It based on the different product. Please be free to consult our salesman.
 
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers. The shelf life will be 2 years.
 
Q6: What's your main payment method?
A: T/T, trade assurance, west union, money gram.
 
Q7: Do you have COA, MSDS, CO, Health certificate, form 9 or other certificate?
A: Yes, we have. pls be free to contact us to get updated one.