High Quality Indomethacin Powder CAS 53-86-1

• Function: Vitamins and Minerals Deficiency Drug
• Grade Standard: Medicine Grade
• Type: Chemical Reagent
• State: Powder
• Volatile: Not Volatile
• CAS: 53-86-1
• Model NO.: py0211
• Mf.: C19h16clno4
• Einecs: 200-186-5
• Standard: USP Bp Ep
• Transport Package: 25kg/Drum
• Specification: 99%
• Trademark: puya
• Origin: China
• Production Capacity: 10ton/Year

Product Description

Indomethacin powder CAS  53-86-1 
Indomethacin, an anti-inflammatory agent, inhibits Cox-1 and Cox-2 (cyclooxygenases) with selectivity for Cox-1 (IC50 of 230 nM) over Cox-2 (IC50 of 630 nM). Additionally, indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis. Other studies show indomethacin to stabilize cholesterol-dependent nanoclusters and enhance phase separation in biological membranes, which could consequentially effect plasma membrane assembled cell signaling cascades. Indomethacin is an activator of PPAR α.

Name: Indometacin
CAS No.: 53-86-1
Formula: C19H16ClNO4
Molecular Weight: 357.79
Synonyms: Indole-3-aceticacid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl- (8CI)
EINECS: 200-186-5
Density: 1.327 g/cm3
Solubility: ethanol: 50 mg/mL
Appearance: White crystalline powder

Specification

ANALYSIS	SPECIFICATION	RESULT
Physical & Chemical Control
Appearance	white crystal powder	Complies
Meeting Point	155ºC-162ºC	158.3ºC
Loss on Drying	≤0.5%	0.13%
Ash Content	≤0.1%	0.07%
Single impurity	≤0.5%	0.12%
Assay by HPLC	99%	Complies

Function
This product has obvious effect on anti-inflammation and antipyretic, can be easily absorbed and excreted. It can be fully absorbed after taken orally in the gastrointestinal tract, and in 1-4 hours the plasma concentration will reach a peak; it will be excreted by liver metabolism, with the urine. It can also be used for acute gout and cancer, fever, or other difficult to control fever.