CAS 14698-29-4 Oxolinic Acid
| Product name |
Oxolinic Acid |
| Appearance |
White powder |
| CAS NO. |
14698-29-4 |
| MF |
C13H11NO5 |
| MW |
261.23014 |
Oxolinic acid is a quinolone antibiotic developed in Japan in the 1970s. Dosages 12-20 mg/kg orally administered for five to ten days. The antibiotic works by inhibiting the enzyme DNA gyrase. It also acts as a dopamine reuptake inhibitor and has stimulant effects in mice.
Function
This product belongs to the first generation of quinolones, and its action mechanism is to inhibit the synthesis of bacterial deoxygenated nucleotides. It has strong antibacterial effect on gram-negative bacteria, but no antibacterial effect on fungi and tuberculous bacteria. The MIC50 was 0.02 ~ 0.09 g/ml. A single oral administration of the product 5mg/kg, 10mg/kg, 20mg/kg and 40mg/kg was given to the carp. After 15-24h, the blood concentration of the drug peaked, and the blood concentration of the drug above 0.2g /ml could reach 66h. This product has extremely low toxicity, and the acute toxicity test for carp oral LD50 is over 4000mg/kg.
Use for :
Quinolinone fungicide, used in the treatment of rice seeds, is known as the first fungicide with excellent effect on rice refractory bacterial disease of grain blight (seedling rot).Before sowing, the bacterial disease caused by grain blight could be inhibited by the treatment of seed dressing, and then the healthy seedling could be prevented by the transplanting of Honda.The mechanism of action was that it had a wide range of antimicrobial activity against Gram-negative function, but had a weak activity against Gram-positive bacteria and no activity against fungi.By inhibiting the synthesis of DNA, it prevents the bacteria from dividing and proliferating.In bacteria, the hypercurly structure of DNA into the reverse hypercurly enzyme, this agent can be combined with the enzyme subgroup A, so that its function is suppressed so that the DNA can not replicate, and soon cause death
Audited Supplier 
Audited Supplier 
){kind=link}
){kind=link}