CAS No.: | 75330-75-5 |
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Formula: | C24h36o5 |
EINECS: | 616-212-7 |
Type: | Pharmaceutical Intermediates |
Appearance: | Powder |
Quality: | Refined |
Samples: |
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Customization: |
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High Quality Lovastatin CAS 75330-75-5
Product Name: Lovastatin
Synonyms: SiMvastatin EP IMpurity E;Lovastatin,Monacolin K;8-[2-(4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-1-nap;6alpha-Methylcompactin Mevinolin Monacolin K;)ethyl]-1-naphthalenylester;[1s-[1alpha(r*),3alpha,7beta,8beta(2s*,4s*),8abeta]]-2-methylbutanoicacid1,2,;1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobuty;2-methyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-butanoicaci
CAS: 75330-75-5
MF: C24H36O5
MW: 404.54
EINECS: 616-212-7
Product Categories: Inhibitor;Heterocycles;chemical reagent;antibiotic;Cardiovascular APIs;Inhibitors;Intermediates & Fine Chemicals;API's;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Isotopically Labeled Pharmaceutical Reference Standard;RYTHYMOL;Antibiotics;APIs;Pharmaceuticals;HMG-CoA reductase;Chiral Reagents
Mol File: 75330-75-5.mol
Lovastatin is a hexahydronaphthyl ester isolated from Aspergillus terreus cultures, an inactive lactone, which is active only after being hydrolyzed after oral administration, and has a strong competitive inhibitory effect on HMG-CoA reductase in the liver. HMG-CoA reductase is the rate-limiting enzyme for ab initio cholesterol synthesis in vivo, and inhibition of this enzyme blocks the conversion of HMG-CoA to methyl valeric acid, resulting in a significant decrease in cholesterol synthesis and causing enhanced expression of hepatic LDL receptors, resulting in enhanced clearance of plasma LDL-C. The reduction in cholesterol synthesis also leads to a reduction in hepatic synthesis of ApoB100 and thus VLDL synthesis. Clinical observation shows that this product has good effect on lowering plasma total cholesterol and LDLC regardless of the various causes of hypercholesterolemia such as heterozygous familial hypercholesterolemia, polygenic hypercholesterolemia, diabetes mellitus or nephrotic syndrome.
Lovastatin CAS 75330-75-5 of Chemical Properties
Melting point 175°C
alpha D25 +323° (c = 0.5 g in 100 ml acetonitri le)
Boiling point 559.2±50.0 °C(Predicted)
density 1.12±0.1 g/cm3(Predicted)
refractive index 320 ° (C=0.5, CH3CN)
storage temp. -20°C
solubility ethanol: soluble9.80-10.20mg/mL, clear, colorless to faintly yellow
pka 13.49±0.40(Predicted)
form White to off-white powder
color White
Water Solubility 0.0004 mg/mL at 25 ºC
Merck 14,5586
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Terms | ||
By Express | By Air | By Sea |
Suitable for under 50kg Fast:3-4 days High cost Door to door service Easy to pick up the goods |
Suitable for more than 50kg Fast:3-4 days High cost Airport to airport Professional broker needed |
Suitable for more than 500kg Slow:15-30 days Low cost Port to port Professional broker needed |
Company Profile
Anhui puya biological technology co.,ltd was established in Hefei. Registered capital is 5 million. It is specialized in manufacture plant extract, API and chemicals raw material powder, food additives and oil. which are applied to skin care, healthcare, weight loss products, sex improvement, and pharmaceuticals. We will uphold honesty and pragmatic, innovative and enterprising service purposes, and provide a variety of quality services to our customers at abroad. It aims at supplying good product and comfort service. The strict quality control is to meet the customer's requirement, to get a highly praised and to be high quality supplier. If you have any question, or need samples, please feel free to contact us.
FAQ
Q1. What's the MOQ?
A: Usually 1 kg. It is based on the different product. Some are 1g and some are 1 ton. Please be free to consult our salesman.
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately. By FedEx will be 3~5 days to you.
Q3. If I need less than the MOQ, is it possible?
A: Yes. Please be free to consult our salesman.
Q4. Can you supply the free sample?
A: Usually it is possible. but the shipping cost be paid by customers. It based on the different product. Please be free to consult our salesman.
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers. The shelf life will be 2 years.
Q6: What's your main payment method?
A: T/T, trade assurance, west union, money gram.
Q7: Do you have COA, MSDS, CO, Health certificate, form 9 or other certificate?
A: Yes, we have. pls be free to contact us to get updated one.
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