Pharmaceutical CAS 120092-68-4 Manidipine/Manidipine HCl

• CAS No.: 120092-68-4
• Formula: C35h38n4o6-2HCl
• EINECS: 680-304-3
• Type: Pharmaceutical
• Appearance: Powder
• Quality: Top
• Model NO.: py0864
• Colour: Yellow
• Standard: USP Bp Ep
• MOQ: 1kg
• Package: Carton
• Shipping: FedEx
• Transport Package: 25kg/Drum
• Specification: 99%
• Trademark: puya
• Origin: China
• Production Capacity: 10ton/Year

Product Description

CAS 120092-68-4  Manidipine/Manidipine HCl
Appearance: Light yellow crystalline solid
Assay :≥99.00%
Density: 1.232 g/cm3
Boiling Point: 722ºC at 760 mmHg
Melting Point: 125-128ºC
Flash Point: 390.4ºC
Storage Condition: -20ºC Freezer
Vapor Pressure: 0.0±2.3 mmHg at 25ºC
Index of Refraction: 1.601
 

Product Name	Manidipine Hydrochloride
CAS NO.	89226-75-5
Purity	99%
Melting Point	228-235 C
Appearance and shape	Yellow powder

A dihydropyridine calcium channel blocker. Antihypertensive. Manidipine (Manyper) is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. It causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells.
Manidipine is a calcium channel blocker that is used clinically as an antihypertensive. Target: Calcium ChannelManidipine is a dihydropyridine calcium antagonist, which causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. Manidipine was well tolerated in clinical trials, with most adverse effects related to vasodilation [1]. Manidipine is a lipophilic, third-generation dihydropyridine calcium channel antagonist with a high degree of selectivity for the vasculature, thereby inducing marked peripheral vasodilation with negligible cardiodepression. manidipine represents a first-line treatment option for patients with essential mild-to-moderate hypertension [2]. Manidipine has neutral effects on glucose and lipid metabolism and is generally well tolerated. Manidipine thus represents a first-line option for lowering BP in patients with mild-to-moderate hypertension [3].

APPLICATION
Manidipine dihydrochloride is a dihydropyridine compound and calcium channel protein inhibitor and antagonist. Calcium antagonist. It has a strong effect of relaxing arterial smooth muscle, dilating blood vessels, reducing peripheral vascular resistance and arterial pressure. For the treatment of essential hypertension, the antihypertensive effect on low-renin hypertension is more obvious, and it can improve the metabolism of uric acid.