Puya Supply Duloxetine HCl CAS 136434-34-9 for Anti Depression

• CAS No.: 136434-34-9
• Formula: C18h20clnos
• EINECS: 603-962-5
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Refined
• Model NO.: PY202211251446
• Colour: White
• Transport Package: 1kg/Aluminum Bag or 25kg/Drum
• Specification: 99% min
• Trademark: Puya
• Origin: China
• Production Capacity: 5000kilogram/Month

Product Description

Puya Supply Duloxetine Hcl CAS 136434-34-9 For Anti Depression

Product Name:    Duloxetine hydrochloride
Synonyms:    Duloxetime;LY-248686 HCl;(γS)-N-methyl-γ-(1-naphthalenyloxy)-2-thiophenepropanamine, hydrochloride (1:1);(+)-N-Methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine hydrochloride;LY-248686 hydrochloride;Duloxetine for system suitability;Duloxetine hydrochloride solution;(S)-N-Methyl-3-(1-naphthalenyloxy)-3-(2-thienyl) propanamine hydrochloride
CAS:    136434-34-9
MF:    C18H20ClNOS
MW:    333.88
EINECS:    603-962-5
Product Categories:    Other APIs;SINGULAIR;Amines;Aromatics;Heterocycles;Sulfur & Seleni um Compounds;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labeled Compounds;Duloxetine;API;136434-34-9
Mol File:    136434-34-9.mol

Duloxetine hydrochloride is the salt form of antidepressant drug duloxetine. It was successfully developed by Eli Lilly Company. Its pharmacological effect is the same as duloxetine. Duloxetine hydrochloride is a new kind of selective dual inhibitor of 5 hydroxy trptamine (5-HT) and norepinephrine reuptake, and thus having antidepressant effect, while also having inhibitory effect on the central pain. Its pharmacological characteristic is being able to inhibit neuronal pre-synaptic membrane's reuptake on 5-hydroxy trptamine and norepinephrine but instead have a low inhibitory effect on the reuptake of dopamine. Duloxetine hydrochloride is indicated for depression and it is effective in treating both endogenous and non-endogenous depression as well as the feeling of pain associated with depression. It has a therapeutic dose of 60mg/d~120mg/d with a good security and fewer adverse reactions with common adverse reactions such as nausea, dry mouth, constipation, poor appetite, fatigue, sleepiness, and increased sweating. Another indication is the pain caused by diabetic neuropathy.

Duloxetine Hcl CAS 136434-34-9 of Chemical Properties
Melting point     118-122°C
Fp     9ºC
storage temp.     room temp
solubility     H2O: soluble5mg/mL (clear solution, warmed)
form     powder
pka    pKa in DMF-water (66:34): 9.6(at 25ºC)
color     white to beige
optical activity    [α]/D +116 to +125°, c = 1 in methan ol
Merck     14,3465

Function and Application of Duloxetine Hcl CAS 136434-34-9

1. Duloxetine Hydrochloride acts as an antidepressant and a dual serotonin and norepinephrine reuptake inhibitor (SNRI) . Exhibits linear pharmacokinetics in mice and is not associated in any drastic changes of blood pressure or heart rate .
2. Duloxetine Hydrochloride is an antidepressant. A dual serotonin and norepinephrine reuptake inhibitor (SNRI). Used in treatment of stress urinary incontinence.
3. Duloxetine Hydrochloride is an anti-depressant, analgesic for osteoarthiritis and musculoskeletal pain


Packing And Shipping
1.Preferentially DHL, FedEX or TNT for quantity less than 50kg, air shipping for 100kg above, sea shipping for quantity over 500kg.
2.For customers from Russia,Mexico,Turkey,Solvenia,Romania,etc,before placing an order,please kindly confirm if you can make clearance when goods reach your customs.

Shipping Terms
By Express	By Air	By Sea
Suitable for under 50kg Fast:3-4 days High cost Door to door service Easy to pick up the goods	Suitable for more than 50kg Fast:3-4 days High cost Airport to airport Professional broker needed	Suitable for more than 500kg Slow:15-30 days Low cost Port to port Professional broker needed

 

Company Profile
Anhui puya biological technology co.,ltd was established in Hefei. Registered capital is 5 million. It is specialized in manufacture plant extract, API and chemicals raw material powder, food additives and oil. which are applied to skin care, healthcare, weight loss products, sex improvement, and pharmaceuticals. We will uphold honesty and pragmatic, innovative and enterprising service purposes, and provide a variety of quality services to our customers at abroad. It aims at supplying good product and comfort service. The strict quality control is to meet the customer's requirement, to get a highly praised and to be high quality supplier. If you have any question, or need samples, please feel free to contact us.

FAQ
Q1. What's the MOQ?
A: Usually 1 kg.  It is based on the different product. Some are 1g and some are 1 ton. Please be free to consult our salesman.
 
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately.  By FedEx will be 3~5 days to you.
 
Q3. If I need less than the MOQ, is it possible?
A: Yes. Please be free to consult our salesman.
 
Q4. Can you supply the free sample?
A: Usually it is possible. but the shipping cost be paid by customers. It based on the different product. Please be free to consult our salesman.
 
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers. The shelf life will be 2 years.
 
Q6: What's your main payment method?
A: T/T, trade assurance, west union, money gram.
 
Q7: Do you have COA, MSDS, CO, Health certificate, form 9 or other certificate?
A: Yes, we have. pls be free to contact us to get updated one.