Top Quality Manidipine CAS 120092-68-4 Pure Manidipine HCl

• Function: Vitamins and Minerals Deficiency Drug
• Grade Standard: Medicine Grade
• Type: Chemical Reagent
• State: Pale Yellow Powder
• Volatile: Not Volatile
• CAS: 89226-75-5
• Model NO.: py0369
• Mf.: C35h40cl2n4o6
• Standard: USP Bp Ep
• MOQ: 1kg
• Transport Package: 25kg/Drum
• Specification: 99%
• Trademark: puya
• Origin: China
• Production Capacity: 10ton/Year

Product Description

CAS 120092-68-4 Manidipine HCl 

Appearance: Light yellow crystalline solid
Assay :≥99.00%
Density: 1.232 g/cm3
Boiling Point: 722ºC at 760 mmHg
Melting Point: 125-128ºC
Flash Point: 390.4ºC
Storage Condition: -20ºC Freezer
Vapor Pressure: 0.0±2.3 mmHg at 25ºC
Index of Refraction: 1.601

Manidipine Dihydrochloride is a metabolite of Manidipine (M16400), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties. Manidipine 2Hcl (CV-4093) is a dihydropyridine compound and a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM. IC50 value: 2.6 nMTarget: calcium channelManidipine is described to block T-type Ca2+ channels specifically and is also described to have a high selectivity for the vasculature, presenting negligible cardiodepression as compared to other Ca2+ channel antagonists. Manidipine is also described to not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation with this compound. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Manidipine, unlike other third-generation dihydropyridine derived drugs, blocks T-type calcium channels present in the efferent glomerular arterioles, reducing intraglomerular pressure and microalbuminuria.

Specification

Test Items	Standard	Test results
Description	A yellow or light yellow crystalline powder	Pale yellow crysalline powder
Melting Point	174~182°C(with decomposition)	176~180°C
Individual impurity	≤0.5%	0.32%
Total impurity	≤1.0%	0.70%
Loss on drying	≤1.0%	0.8%
Sulphate ash	≤0.1%	0.07%
Heavy Metals	≤0.002%	<0.002%
Assay	98.0%~101.5%	99.30%
Conclusion	conforms with enterprise standard

Function
Manidipine dihydrochloride is a dihydropyridine compound and calcium channel protein inhibitor and antagonist. Calcium antagonist. It has a strong effect of relaxing arterial smooth muscle, dilating blood vessels, reducing peripheral vascular resistance and arterial pressure. For the treatment of essential hypertension, the antihypertensive effect on low-renin hypertension is more obvious, and it can improve the metabolism of uric acid...

Application
Manidipine dihydrochloride is a dihydropyridine compound and calcium channel protein inhibitor and antagonist. Manidipine is described to block T-type Ca2+ channels specifically and is also described to have a high selectivity for the vasculature,presenting negligible cardiodepression as compared to other Ca2+ channel antagonists. Manidipine is also described to not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation with this compound.