CAS No.: | 141505-33-1 |
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Formula: | C14h12n6o |
EINECS: | 663-528-6 |
Type: | Pharmaceutical Intermediates |
Appearance: | Powder |
Quality: | Refined |
Samples: |
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High Quality Levosimendan CAS 141505-33-1 Treatment Of Acute Heart Failure
Product Name: Levosimendan
Synonyms: LEVOSIMENDAN;-2-[[4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)19henyl]hydrazono]Propandinitrile;(R)-Simendan;[[4-[(4R)-1,4,5,6-Terahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazono]propanedinitrile;OR-1259;Simda;Mesoxalonitrile (-)-{p-[(R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl}hydrazone;(R)-2-[[4-(1,4,5,6-TETRAHYDRO-4-METHYL-6-OXO-3-PYRIDAZINYL)PHENYL] HYDROZONO]PRO
CAS: 141505-33-1
MF: C14H12N6O
MW: 280.28
EINECS: 663-528-6
Product Categories: Inhibitors;FLUOTHANE;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 141505-33-1.mol
Levosimendan was introduced in Sweden as an i.v. infusion for the treatment of acute heart failure or refractory symptoms of chronic heart failure in cases where conventional treatment (e.g., diuretic or ACE inhibitor) is not sufficient. Levosimendan is the (R)- enantiomer of simendan that belongs to the same class as pimobendan (Boehringer Ingelheim). Levosimendan is an innovative myofilament calcium sensitizer that increases myocardial contractility by selectively binding to the N-terminus of troponin C and by stabilizing the Ca2+-bound conformation of this contractile protein. It also activates ventricular and arterial adenostne triphosphate-regulated potassium channels which causes vasodilatation in vascular smooth muscle and protects myocardium against infarction. Its low phosphodiesterase III inhibiting activity is probably not responsible for its positive inotropic, lusitropic and dilating effects. Unlike other cardiotonic drugs, levosimendan is able to produce positive inotropic effects without prolonging myocardial relaxation or increasing the incidence of malignant arrythmias. It was clinically shown to have a lower risk of mortality in patients with heart failure when compared to placebo and dobutamine. Since it has a larger potential, levosimendan is currently under further clinical evaluation as a chronic treatment for congestive heart failure.
Levosimendan CAS 141505-33-1 of Chemical Properties
Melting point 216-219°C (dec.)
alpha D25 -566° (tetrahydrofurane/methan ol)
density 1.33±0.1 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: ≥20mg/mL
form powder
pka 6.3(at 25ºC)
color yellow
optical activity [α]/D -500 to -650°, c = 0.5 in THF
Function and Application of Levosimendan CAS 141505-33-1
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Company Profile
Anhui puya biological technology co.,ltd was established in Hefei. Registered capital is 5 million. It is specialized in manufacture plant extract, API and chemicals raw material powder, food additives and oil. which are applied to skin care, healthcare, weight loss products, sex improvement, and pharmaceuticals. We will uphold honesty and pragmatic, innovative and enterprising service purposes, and provide a variety of quality services to our customers at abroad. It aims at supplying good product and comfort service. The strict quality control is to meet the customer's requirement, to get a highly praised and to be high quality supplier. If you have any question, or need samples, please feel free to contact us.
FAQ
Q1. What's the MOQ?
A: Usually 1 kg. It is based on the different product. Some are 1g and some are 1 ton. Please be free to consult our salesman.
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately. By FedEx will be 3~5 days to you.
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Q4. Can you supply the free sample?
A: Usually it is possible. but the shipping cost be paid by customers. It based on the different product. Please be free to consult our salesman.
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A: Store in cool and dry place. It must be in well closed containers. The shelf life will be 2 years.
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A: Yes, we have. pls be free to contact us to get updated one.
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