| CAS No.: | 58970-76-6 |
|---|---|
| Formula: | C16h24n2o4 |
| EINECS: | 261-529-2 |
| Type: | Pharmaceutical Intermediates |
| Appearance: | Powder |
| Quality: | Refined |
| Customization: |
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Audited Supplier High Quality Bestatin CAS 58970-76-6 For Anti Tumour
Product Name: Bestatin
Synonyms: UBENIMEX;UbenaMix, Inobestin, NK 421;L-Leucine,N-[(2S,3R)-3-aMino-2-hydroxy-1-oxo-4-phenylbutyl]-;N-[(2S,3R)-3-AMino-2-hydroxy-4-phenylbutyryl]-L-leucine 97%;3-(r)-amino-2-(s)-hydroxy-4-phenylbutanoyl-(s)-leucine;n-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-,(s-(r*,s*))-l-leucin;nk421;Bestatin - CAS 58970-76-6 - Calbiochem
CAS: 58970-76-6
MF: C16H24N2O4
MW: 308.37
EINECS: 261-529-2
Product Categories: ProteaseInhibitors;Ubenimex;Active Pharmaceutical Ingredients;Pepetides;peptides;Bestatin
Mol File: 58970-76-6.mol
Bestatin is an aminopeptidase inhibitor originally isolated from S. olivoreticuli. It inhibits aminopeptidase B (IC50 = 0.05 μg/ml), aminopeptidase N (IC50 = 16.9 μM), leucine aminopeptidase (IC50 = 0.01 μg/ml), and the aminopeptidase activity of leukotriene A4 (LTA4) hydrolase (Kapp = 172 nM). It is selective for these aminopeptidases over aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, and thermolysin. Bestatin inhibits the production of LTB4 in erythrocytes when used at a concentration of 70 μM. It increases the expression of Akt, inhibits proliferation, migration, and invasion, and induces autophagy and apoptosis in 5637 bladder cancer cells. Bestatin (5 and 15 mg/kg) decreases serum levels of LTB4 and reduces tumor growth in a patient-derived xenograft (PDX) mouse model of colorectal cancer.
Bestatin CAS 58970-76-6 of Chemical Properties
Melting point 245 °C (dec.)(lit.)
alpha D20 -15.5° (c = 1.0 in 1N HCl)
Boiling point 448.76°C (rough estimate)
density 1.0917 (rough estimate)
refractive index 1.5800 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Aqueous Acid (Slightly, Sonicated), DMSO (Slightly, Heated), Methan ol (Slightly,
pka 8.1, 3.1(at 25ºC)
form Powder
color White
optical activity [α]20/D 11°, c = 1 in 1 M NaOH
Water Solubility Soluble in water (<1 25), DMSO (2 mg/ml), methan ol (5 mg/ml), 1eq. NaOH (50 mM), ethanol (<1 mg/ml at 25°C), acetic acid, aq. HCl, and alkaline solution. Insoluble in ethyl acet ate, benzene, hexa ne, and chlorof orm.
Merck 13,9910
InChIKey VGGGPCQERPFHOB-RDBSUJKOSA-N
CAS DataBase Reference 58970-76-6(CAS DataBase Reference)
Function and Application of Bestatin CAS 58970-76-6
Bestatin (CAS 58970-76-6) is a natural inhibitor of aminopeptidase B, a type of enzyme that plays a role in the breakdown of proteins. Bestatin has been shown to have various biological activities, including immunomodulatory, antitumor, and antiviral effects.
One of the main functions of Bestatin is to inhibit the activity of aminopeptidase B, which is involved in the breakdown of various peptides and proteins. By inhibiting aminopeptidase B, Bestatin can increase the concentration of peptides and proteins in the body, leading to various biological effects.
Some of the applications of Bestatin include:
Anticancer agent: Bestatin has been shown to inhibit the growth of various cancer cells in vitro and in vivo, and is currently being investigated as a potential anticancer agent.
Immune system modulator: Bestatin has been shown to enhance the activity of natural killer cells and T cells, which play an important role in the immune response against infections and cancer cells.
Antiviral agent: Bestatin has been shown to inhibit the replication of various viruses, including HIV, herpes simplex virus, and hepatitis C virus.
Treatment for autoimmune diseases: Bestatin has been shown to suppress the development of autoimmune diseases by modulating the activity of immune cells.
| Shipping Terms | ||
| By Express | By Air | By Sea |
| Suitable for under 50kg Fast:3-4 days High cost Door to door service Easy to pick up the goods |
Suitable for more than 50kg Fast:3-4 days High cost Airport to airport Professional broker needed |
Suitable for more than 500kg Slow:15-30 days Low cost Port to port Professional broker needed |
Company Profile
Anhui puya biological technology co.,ltd was established in Hefei. Registered capital is 5 million. It is specialized in manufacture plant extract, API and chemicals raw material powder, food additives and oil. which are applied to skin care, healthcare, weight loss products, sex improvement, and pharmaceuticals. We will uphold honesty and pragmatic, innovative and enterprising service purposes, and provide a variety of quality services to our customers at abroad. It aims at supplying good product and comfort service. The strict quality control is to meet the customer's requirement, to get a highly praised and to be high quality supplier. If you have any question, or need samples, please feel free to contact us.
FAQ
Q1. What's the MOQ?
A: Usually 1 kg. It is based on the different product. Some are 1g and some are 1 ton. Please be free to consult our salesman.
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately. By FedEx will be 3~5 days to you.
Q3. If I need less than the MOQ, is it possible?
A: Yes. Please be free to consult our salesman.
Q4. Can you supply the free sample?
A: Usually it is possible. but the shipping cost be paid by customers. It based on the different product. Please be free to consult our salesman.
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers. The shelf life will be 2 years.
Q6: What's your main payment method?
A: T/T, trade assurance, west union, money gram.
Q7: Do you have COA, MSDS, CO, Health certificate, form 9 or other certificate?
A: Yes, we have. pls be free to contact us to get updated one.
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